Your Brain on LSD and Acid

LSD, also known as acid, It is a psychedelic drug that will change your perception and make you hallucinate. But how does it affect your body and your head? In 1938, humans first extracted and synthesized Lysergic acid diethylamide from a fungus growing on rye. In 1943, the inventor Albert Hofmann accidentally ate some LSD on his fingers. He was high, and became the first person in the world to understand the psychedelic effects of LSD.

In the 1950s and 1960s, people studied this drug. But as recreational use began to proliferate, Psychedelic drugs were classified as illegal drugs in the United States (American Standard Schedule I), and research projects were stopped. Generally, the dosage of drugs is calculated in grams, and the amount of a serving of LSD is one hundred thousandths of a gram. It is about one-tenth the weight of a grain of sand. LSD affects many brain receptors, such as dopamine receptors, adrenergic receptors, and glutamate receptors. But most research focuses on the stimulation of serotonin receptor 5H2TA, LSD binds to the receptor through an abnormal angle, causing the receptor to cover the LSD, Then LSD is trapped in the receptors, constantly generating signals to the nerve receptors, causing you to hallucinate.

By absorbing 5TH2A receptors into cells, your body will slowly break down LSD, But this may take more than 12 hours, so the psychedelic effect can last a long time. Recently, there has been more research on LSD, with modern neural image technology, Researchers have found that this drug can make some parts of your brain communicate very strange, especially in the visual cortex. This may explain those complex and bright (visual) hallucinations. The blood flow in the Default mode network has also increased, which may be related to a strong change in consciousness. This feeling is called “self-dissolving”, which means that the boundaries that separate you from the things around you no longer exist and you “melt” into the world. Many people say that this feeling makes them seem to re-establish a connection with themselves, others, and the natural world. In one study, 20 healthy volunteers who took 75 micrograms of LSD were observed. 2 weeks later, Their scores for optimism and openness in the personality assessment were improved.

Creativity and imagination have also increased. This led researchers to consider whether LSD could be used as a treatment for death anxiety and life-threatening diseases. Researchers found that 12 months after taking LSD, patients’ anxiety decreased, The quality of life has improved, and drugs (LSD) have helped them re-establish their habits and worldview. This is why the trend of low-dose use is rising, Taking only one-tenth of the usual recreational dose, people try to skip hallucinations, Just experience the increased awareness, vitality, and creativity. Although LSD is considered not to be addictive, researchers also assessed it as much less dangerous than other drugs. Such as cocaine and heroine. But there is very little scientific research to explain Why is the use of small doses so popular, and even experienced psychedelic users sometimes experience bad things, There is unprovoked fear, paranoia, and panic.

LSD may also flash back, even if a few months have passed, You can also feel the effect of the medicine again. In some extreme cases, Some people will get Hallucinogen Persisting Perception Disorder, which means hallucinations are always there. It is an exaggeration to think that LSD will cause mental illness or suicide. In the US survey, among those who have used psychedelics (14% of the participants) No increased risk of mental illness, depression, or suicide was found. But research on the potential positive effects of LSD is also very shallow. So you better not try. Want to learn more about the effects of drugs on your brain? Check out our playlist, which introduces many other substances, And how they affect you.

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